Following the review in my PCPowerPlay150, Sins of a Solar Empire looks like it could make a nifty lure for the RTS genre. Despite the 2Dness of the universe, it looks expansive. I would like to see greater differences between the races than it looks like we get (ala starcraft).
I like the 4X concept of games: eXplore, eXpand, eXploit and eXterminate.
The interface seems to be one of the great advances and the trailer below sets the mood pretty well.