One of the great joys with my iPod is being able to keep up with a series of podcasts, which I do via iTunes. The regulars on my plate are the Science Show from ABC Radio National, The Sceptics Guide to the Universe, Science Talk (Scientific American), The Naked Scientists and the Nature Podcast. There are a handful of others (esp video ones) that I only get to catch up with in bursts like The TED Talks, Good Game, The Philosophers Zone and a few gaming/vfx ones here and there.
This concept of being able to listen to information as well as music is a nice step forward that is empowered by being able to subscribe to your weekly dose of something that tickles your fancy.
Oh and having the ability to just popp over and buy an album is all too tempting...